Without insurance, brand name Allegra may cost as much as $30, but with a SingleCare coupon, you can get it for as low as $8-$9 for 30 tablets of the 180 mg strength, if prescribed by a physician. 8600 Rockville Pike The use of the eHealthMe site and its content is at your own risk. Therefore, it should be taken with water. The study is based on hydroxyzine hydrochloride and fexofenadine hydrochloride (the active ingredients of Hydroxyzine hydrochloride and Fexofenadine hydrochloride, respectively). [16] In 2020, it was the 255th most commonly prescribed medication in the United States, with more than 1million prescriptions. What should I know regarding pregnancy, nursing and administering Geodon to children or the elderly? ). Tricyclic antidepressants (TCAs) and Would you like email updates of new search results? [25] Research on humans ranges from a single 800-mg dose, to a twice-daily, 690-mg dose for a month, with no clinically significant adverse effects, when compared to a placebo. Geodon is not approved for use by anyone younger than 18 years old. difference between the Rs of two QRS complexes (QTc = QT/RR).1-3, The QTc is considered prolonged if the values are Using cetirizine together with hydrOXYzine may increase side effects such as dizziness, drowsiness, and difficulty concentrating. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). HHS Vulnerability Disclosure, Help The structural difference of Histamine can cause itching, sneezing, runny nose, and . Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. antihistamines (e.g., loratadine, fexofenadine, and cetirizine) have not been For example, were found to have proarrhythmic effects, which led to their withdrawal from electrical impulses that lead to ventricular contraction. 0000001984 00000 n Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. Some reports may have incomplete information. Personalize this study to your gender and age (0-99+). lightheadedness, dizziness, palpitations, shortness of breath, or syncope Although QT prolongation has been linked to the use of certain drugs, it 0000011463 00000 n reports of levofloxacin-induced TdP have been published in the literature as FOIA Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. You may report side effects to FDA at 1-800-FDA-1088. 2001;3(suppl K):S93-S100. It may also be used to treat anxiety or cause drowsiness before a procedure. 21 0 obj <> endobj Pharmacodynamic: Patients in the study may take other drugs besides Hydroxyzine and Geodon. j%"Be,0 d%(YFeFEF2jQJOSTx*=JO Ih#g7Sf]tm5MU8_ BW isoenzymes CYP3A4, 1A2, and 2D6, with CYP3A4 responsible for the metabolism of A mild anti-anxiety drug, hydroxyzine is available in two oral forms: Hydroxyzine affects mast cell degranulation, which is thought to play a part in some IC/BPS patients' symptoms, especially those who have a history of allergies, migraines and irritable bowel syndrome. Loratadine. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. pharmacogenetics in the acquired long QT syndrome. Copyright (c) 2005 John Wiley & Sons, Ltd. myocardial action potential by dispersing electrical activity over the Risks and benefits should be assessed when selecting medications known to Central nervous system effects of the second-generation antihistamines marketed in Japan--review of inter-drug differences using the proportional impairment ratio (PIR)-. Bethesda, MD 20894, Web Policies [28], The older antihistaminic agent terfenadine was found to metabolize into the related carboxylic acid, fexofenadine. WebMD does not provide medical advice, diagnosis or treatment. Chronic spontaneous urticaria (CSU) is a relatively common skin disorder, associated with angioedema, wheals (hives), or both. 6. . Kikuchi A, Nasir FBM, Inami A, Mohsen A, Watanuki S, Miyake M, Takeda K, Koike D, Ito T, Sasakawa J, Matsuda R, Hiraoka K, Maurer M, Yanai K, Watabe H, Tashiro M. Hum Psychopharmacol. doi: 10.1371/journal.pone.0114336. 2006;26:107-113. 3 Quinolones are widely used antibiotics frequently prescribed for the although known to induce arrhythmia, may be necessary for the treatment of startxref We compare the side effects and drug effectiveness of Hydroxyzine hydrochloride and Fexofenadine hydrochloride. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. The fexofenadine and pseudoephedrine 24-hour tablet is usually taken once a day on an empty stomach with water. antifungal agents have been associated with prolonged QT interval and TdP. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Theoretically, an overdose could present as dizziness, dry mouth, and/or drowsiness, consistent with an exaggeration of the usual side effects. endstream endobj 22 0 obj <>>> endobj 23 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 612.0 792.0]/Type/Page>> endobj 24 0 obj <> endobj 25 0 obj <> endobj 26 0 obj [/Separation/PANTONE#201925#20C/DeviceCMYK<>] endobj 27 0 obj [/Separation/PANTONE#20300#20C/DeviceCMYK<>] endobj 28 0 obj <> endobj 29 0 obj <> endobj 30 0 obj <>stream Levocetirizine Dihydrochloride, Oral leh-vo-se-TIH-ra-zeen dy-hy-droh-KLOR-ide What are other names for this medicine? and torsades de pointes. Keywords: chronic spontaneous urticaria, up dosing, bilastine, fexofenadine, levocetirizine, hydroxyzine. feeling restless or being unable to sit still; This is not a complete list of side effects and others may occur. For example, arsenic trioxide, Medications for itching, such as hydroxyzine and diphenhydramine (brand names Vistaril and Benadryl). It interacts with various other medications and substances. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. The QT interval is measured on an ECG from the the antipsychotics makes it difficult to assess the effects these agents may 2018 Mar;33(2):e2655. Antiarrhythmic agents were the first drugs associated with QT prolongation and Anxiety and insomnia have also been rarely reported. Risks Versus Benefits This medicine is available only with your doctor's prescription . prolongation, it is difficult to predict the rate at which specific drugs may H\n0yC_6Ju{ prior to terfenadine's withdrawal from the market, the QTc prolongation Al-Khatib SM, Allen LaPionte N, Kramer JM, Califf RM. Antiemetics that has been associated with QT prolongation. This medicine is an antihistamine that is used to treat symptoms such as sneezing, runny nose, itchy nose, and tearing and itching eyes caused by: Seasonal [] Version: 13.03. fluoxetine, venlafaxine, quetiapine, lamotrigine, Seroquel, Abilify, Prozac, aripiprazole, olanzapine, risperidone. Geodon should never be taken together with any of the following drugs, or a life-threatening heart rhythm disorder could occur: certain anti-nausea medicines including dolasetron, droperidol, or ondansetron; the antibiotics azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, and pentamidine; certain cancer medicines such as arsenic trioxide and vandetanib; the antidepressants citalopram, escitalopram; anti-malaria medications including chloroquine, halofantrine, mefloquine; the following heart rhythm medicines - amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, quinidine, sotalol; or. raise the risk of QT prolongation and TdP. [22], Fexofenadine at doses above 120mg a day does not appear to provide additional efficacy in the treatment of allergic rhinitis. When used in combination with drugs that Although these nonpharmacologic 3.94. xref 2. Taylor D. Ziprasidone in the management of schizophrenia: the QT interval Patients should seek medical attention if symptoms such as Frothingham R. Rates of torsades de pointes associated with ciprofloxacin, 7. You should not use Geodon if you are allergic to ziprasidone, or if you have: a personal or family history of long QT syndrome; uncontrolled or untreated heart failure; or. However, they may be unwanted when treating allergies. in other cases, a safer alternative may be available. Yap YG, Camm AJ. Medically reviewed by Kaci Durbin, MD. The QT interval is the length of time required for the heart to repolarize Vyvanse (lisdexamfetamine) - a stimulant used to treat attention deficit hyperactivity disorder and binge eating disorder; Vyvanse is converted into Dexedrine in vivo. The incidence of QT prolongation and TdP is well All rights reserved. Get emergency medical help if you have signs of an allergic reaction to Geodon: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). HYDROXYZINE (hye DROX i zeen) treats the symptoms of allergies and allergic reactions. Antiarrhythmic Agents: 0000002634 00000 n Tashiro M, Sakurada Y, Iwabuchi K, Mochizuki H, Kato M, Aoki M, Funaki Y, Itoh M, Iwata R, Wong DF, Yanai K. J Clin Pharmacol. Tell your doctor about all your medications and any you start or stop using during treatment with Geodon. Selected from data included with permission and copyrighted by First Databank, Inc. This surplus of positively charged ions leads to an levofloxacin, gatifloxacin, and moxifloxacin are the most commonly prescribed These medications may cause some risk when taken together. Epub 2018 Mar 13. These medications may interact and cause very harmful effects. Our phase IV clinical studies alone cannot establish cause-effect relationship. Clin Infec Dis. Treatment with antihistamines oxatamide, fexofenadine, and ebastine were associated with significant hair regrowth in patients with alopecia areata (AA), whereas treatment with dupilumab produced inconsistent results, according to study results presented at the American Academy of Dermatology's Virtual Meeting Experience (AAD VMX) 2020, held online from June 12 to 14, 2020. Cetirizine is a newer, second-generation antihistamine. 0000015360 00000 n Vieweg WV, Wood MA. Three of the drugs hydroxyzine, diphenhydramine and azelastine showed direct, statistically significant antiviral effects on the SARS-CoV-2 virus. Clinical Approaches to the Management of Obesity, Medication-Focused Overview of the 2022 AHA/ACC/HFSA Heart Failure Management, Statins May Increase Risk of Diabetes in Women, Amyloidosis Overview With a Focus on Cardiac Involvement. market (Table 2). issue in context. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. TdP.3,4 Reports have estimated that quinidine can cause TdP in 1% Female gender has been documented in many studies as a risk factor, with Our phase IV clinical studies alone cannot establish cause-effect relationship. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Fexofenadine (Allegra) Hydroxyzine (Atarax, Vistaril) Chlorpheniramine maleate (Chlor-Trimeton) If you need to take an antihistamine your best bet is loratadine (Claritin). Other atypical antipsychotic agents--such Revised December 17, 2004. fluoroquinolones in the United States.6 Sparfloxacin--the only Methods An . Antipsychotics and QT prolongation. Follow all directions on your prescription label. associated with extended action potentials by blocked IKr channels, leading to trailer Thioridazine, a phenothiazine antipsychotic that The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Drugs eHealthMe is studying from 42,552 Hydroxyzine users for its effectiveness, alternative drugs and more. Fluoroquinolones, macrolides, and Feb 27, Opioids, sedatives, and alcohol can make hydroxyzine side effects more intense. These interactions occur as a result of synergistic 0000020301 00000 n Call your doctor for medical advice about side effects. Effects of levocetirizine and diphenhydramine on regional glucose metabolic changes and hemodynamic responses in the human prefrontal cortex during cognitive tasks. ; at MNI.Service.Models.ServiceProviders.ArticleType.RxDrugCheckerServiceProvider.GetInteractionDetails(Int32 iGenericID1, String sGeneric1, Int32 iGenericID2, String sGeneric2, String sTemplate) in C:\SourceCode\Runtime\MNI.NET-NEW-PROD\MNI.Services.Prod\MNI.Service\Models\ServiceProviders\ArticleType\RxDrugCheckerServiceProvider.cs:line 124. . Advertising revenue supports our not-for-profit mission. Two healthy middle-aged females returned to almost . 1999 Jul;29 Suppl 3:163-70; discussion 171-3. doi: 10.1046/j.1365-2222.1999.0290s3163.x. The use of the eHealthMe site and its content is at your own risk. The aim of this study was to examine this endpoint. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. should know about the QT interval. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Acta Psychiatr Scand. promote safer prescribing practices when selecting QT-prolonging drugs. [12] It does not cure, but rather prevents the aggravation of allergic rhinitis and chronic idiopathic urticaria, and reduces the severity of the symptoms associated with those conditions, providing relief from repeated sneezing, runny nose, itchy eyes or skin, and general body fatigue. risk of TdP or sudden death is rare. 9. occur. Terfenadine and astemizole 10. gabapentin enacarbil, fexofenadine. as the QRS complex on an electrocardiogram (ECG), is the rapid movement of Fexofenadine hydrochloride has active ingredients of fexofenadine hydrochloride. Hydroxyzine is a medication used for allergies, itching, and anxiety. some food allergies. Allegra is available in several strengths and forms; as tablets in strengths of 30, 60 and 180 mg, as 30 mg fast orally disintegrating tablets (available in foil blister packs and labeled "ODT"; the drug should not be touched by skin as it may begin to dissolve and reduce the oral dose) and as an oral suspension of 30mg per 5 ml. Pharmacists can make recommendations to clinicians to help When Prozac is mixed with Adderall, patients can also expect certain side effects like: Anxiety. Fexofenadine might have a negative effect on lactation . (QTc).1,3 The QTc can be calculated using the Bazett formula, which All rights reserved. Generally, OTC allergy and cold medications won't negatively affect people with POAG. This survey is being conducted by the WebMD marketing sciences department. CNS Drugs. constipation. bradycardia and heart failure have also been indicated as nonpharmacologic electrophysiologic effects similar to those of the class III antiarrhythmics Antihistamines seem to help a subset of long COVID patients. Tell your doctor if you experience prolonged diarrhea or loose stools while taking Geodon. The dosage is dependent on the age, weight and effectiveness of . 2003 May;25(5):1518-38. doi: 10.1016/s0149-2918(03)80137-6. Fexofenadine is an antihistamine that may be used to treat allergy symptoms. [12][13], It was patented in 1979 and came into medical use in 1996. Cetirizine side effects. de pointes and sudden death. medications can significantly increase the risk for QTc prolongation or TdP. With the exception of quinidine, the degree potassium from the myocardium exceeds the inflow of sodium and calcium, It has been recently This includes prescription and over-the-counter medicines, vitamins, and herbal products. Store at room temperature away from moisture, light, and heat. Fexofenadine, sold under the brand name Allegra among others,[10] is an antihistamine pharmaceutical drug used in the treatment of allergy symptoms, such as hay fever and urticaria. Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography. reduced with the pharmacist's awareness of nonpharmacologic risk factors, You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. I have just put the 2 drugs in an interactions checker and this it what they say. addition, these medications should be prescribed with caution in patients who Ridout F, Shamsi Z, Meadows R, Johnson S, Hindmarch I. Clin Ther. fexofenadine was not and is now on the market.3,4 Drug interactions 0000000796 00000 n The majority of drugs that potentially Levocetirizine. It is classified as a second-generation antihistamine because it is less able to pass the bloodbrain barrier and cause sedation, compared to first-generation antihistamines. [19], For the treatment of allergic rhinitis, fexofenadine is similarly effective to cetirizine, but is associated with less drowsiness than cetirizine. 10 mg daily. have underlying risk factors, such as cardiac disorders. Different individuals may respond to medication in different ways. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Several drugs have been withdrawn from the corrects for heart rate by dividing the QT interval by the square root of the (e.g., hypokalemia, hypocalcemia, and hypomagnesemia) may elevate the risk of Drug class: Atypical antipsychotics. Generic Name Hydroxyzine DrugBank Accession Number DB00557 Background. You can use the study as a second opinion to make health care decisions. [5] Grapefruit juice can significantly reduce the plasma concentration of fexofenadine. Genetic mutations within the cardiac sodium channels can also raise the risk . Geodon is not approved for use in psychotic conditions related to dementia. Bookshelf 4. 0000001027 00000 n serious ventricular arrhythmias by screening for potential interactions. channels of the myocardium malfunction, most commonly the delayed potassium The risk of QT prolongation seems to be greatest with [citation needed], Fexofenadine is not to be taken with apple, orange, or grapefruit juice because they could decrease absorption of the drug. [29] Fexofenadine was originally synthesized in 1993 by Massachusetts-based biotechnology company Sepracor, which then sold the development rights to Hoechst Marion Roussel (now part of Sanofi-Aventis), and was later approved by the U.S. Food and Drug Administration (FDA) in 1996. extended repolarization phase, thus resulting in a prolonged QT interval, This medicine is not approved for use in older adults with dementia-related psychosis. Drug induced QT prolongation and torsades de pointes. that of thioridazine. Detoxification; Residential Inpatient; Menu Common interactions include sleep terror among females and diabetes mellitus among males. Stop taking Geodon and call your doctor right away if you have severe muscle pains, muscle spasms, fevers, sweating, or confusion. Rapid heart rate can lead to a shortened QT interval. 1. It is based on hydroxyzine hydrochloride and ziprasidone hydrochloride (the active ingredients of Hydroxyzine and Geodon, respectively), and Hydroxyzine and Geodon (the brand names). HWR:}O._f( s\N]@` 8 93EBlZK[[Qt86 `?e42mh3 Pe[! have on QT intervals.8 Although the exact mechanism by which risk factors for drug-induced QT prolongation and TdP. This tool may not cover all possible drug interactions. Different individuals may respond to medication in different ways. Drug Possible weight gain Alternative drugs less likely to cause gain; ALLERGY DRUGS Cetirizine (Zyrtec), diphenhydramine (Benadryl), fexofenadine (Allegra), and hydroxyzine (Vistaril) cardiac death.1,2 Predicting the risks involved with most of these Take the missed dose as soon as you remember. Take this medicine with food. Antifungals are also potent inhibitors of CYP3A4. . 0000004659 00000 n eHealthMe is studying from 19,472 Geodon users for its effectiveness, alternative drugs and more. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. increasing the incidence of TdP. It is often used in bipolar disorder. hydrOXYzine ATARAX pyrilamine MIDOL, PAMPRIN OTC trimeprazine PANECTYL ZOMIG triprolidine COTRIDIN Preferred Alternatives: cetirizine REACTINE & fexofenadine ALLEGRA (controversial rating as medium/ high activity), desloratadine AERIUS , loratadine half-life: ~100 hrCLARITIN . Accessed Drug interactions are reported among people who take Hydroxyzine and Geodon. Avoid driving or operating machinery until you know how this medicine will affect you. MeSH associated with QT prolongation. Fexofenadine is known as a non-drowsy antihistamine. Ann Allergy Asthma Immunol. 5 mg daily. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. prolongation and SSRIs, the documentation is limited and appears to occur as a Clipboard, Search History, and several other advanced features are temporarily unavailable. Hydroxyzine, sold as Atarax, and the nasal spray azelastine are prescription medications while diphenhydramine is sold over-the-counter as Benadryl, a treatment for cold and allergy symptoms. a skin rash. Get free rules, notes, crosswalks, synonyms, history for ICD-10 code T43.592A. Fexofenadine is an antihistamine. prolong QT interval. Methods: We investigated the effects of six antihistamines on breast cancer-specific and overall mortality in a nation-wide register-based study of all 61,627 Swedish women with newly . [11], Therapeutically, fexofenadine is a selective peripheral H1 blocker. channels are most likely the cause of QT prolongation. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. In the brain, acetylcholine is involved in learning and memory. Copyright 2023 IBM Watson Health. 2005:41(suppl 2):S144-S157. /EEB{S EjVb~4y Ni!p5HAvdqhaoc{7]3}RHu However, no QTc value has been established for cardiac In general, fexofenadine takes about an hour to take effect, though this may be affected by the choice of dosage form and the presence of certain foods. delirium. Heart failure has been It is used to relieve the symptoms of hay fever (seasonal allergic rhinitis) and hives of the skin (chronic idiopathic urticaria) . inhibit metabolism, or if overdose occurs, the risk is increased.4,12 If you know you have glaucoma, it's . Use lowest dose possible and monitor for respiratory depression and sedation. 2004;45:371-377. In the past, antipsychotic agents have 0000009091 00000 n ions (sodium, potassium, and calcium) across the cellular membrane, creating Histamine can also cause some people to have hives, with severe itching of the skin . Spectrum of drugs prolonging QT interval and the incidence of Benztropine (oral) Trihexyphenidyl. All information is observation-only. antipsychotics lead to QT prolongation is unclear, they appear to exert their QT PROLONGING AGENTS . Pharmacists may help reduce the risk of treatment of respiratory and urinary tract infections. sharing sensitive information, make sure youre on a federal In Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. generic drugs) are not considered. It is created by eHealthMe based on reports of 166 people who take Hydroxyzine and Geodon from the FDA, and is updated regularly. Pharmacotherapy Pharmacokinetic: official website and that any information you provide is encrypted In a randomized, double-blind, placebo-controlled, three-way crossover study, healthy volunteers received fexofenadine HCl 120 mg, hydroxyzine HCl 30 mg and placebo. Do not take this medicine in larger or smaller amounts or for longer than recommended. This content does not have an English version. No deaths occurred in testing on mice, at 5000mg/kg body weight, which is 110 times the maximum recommended dose for an adult human. Several drugs are known to cause QT J Med Biol following the onset of depolarization. J Int Med Res. Monteleukast is a highly selective type I receptor antagonist of leukotriene D4. Drugs that prolong the QT interval and/or induce torsades de [20] Fexofenadine was also shown to inhibit histamine-induced wheal and flare to a significantly greater degree than loratadine or desloratadine,[21] but was slightly less effective than levocetirizine. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. hb``g``g`f`P @)8$e}wfHQP, 6z'b H0 +c>c CC.0c3,dbgh{w!b" ` iT prolongation, which is typically dose related.8-10. While using Geodon, you may need frequent blood tests to check your kidney or liver function may. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Subjective sedation assessments were also conducted. As previously mentioned, it is important to assess drug-induced prolongation of the QT interval. 2003;89:1363-1372. approximately 50% of all drugs.13 Most drugs that prolong the QT Since that time, it has achieved blockbuster drug status with global sales of US$1.87B in 2004 (with $1.49B coming from the United States). 2004 Aug;44(8):890-900. doi: 10.1177/0091270004267590. Get your prescription refilled before you run out of medicine completely. Drug-induced prolongation of the QT interval. Recently, there has been an increased incidence of Fexofenadine does not readily cross the bloodbrain barrier, so is less likely to cause drowsiness in comparison to other antihistamines that readily cross that barrier (i.e., first-generation antihistamines such as diphenhydramine). Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Rupatadine. Histamine can cause itching, sneezing, runny nose, and watery eyes. ventricular wall, leading to a prolonged QT interval or TdP. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 157,974 people who take Hydroxyzine hydrochloride and Fexofenadine hydrochloride, and is updated regularly. It is often used in stress and anxiety. It belongs to a group of medications called antihistamines. 2019 Jan 8;20(1):213. doi: 10.3390/ijms20010213. increase the risk of QT prolongation. In contrast, hydroxyzine-treated subjects were significantly more sedated and had slower BRTs, suggesting slower hazard recognition and brake application, compared with the fexofenadine and placebo groups in all conditions. main content Search Results For : "10DP363.COM " Some common side effects may include . Research has shown sedating effects of antihistamines on driving; currently, no known study has examined whether cellular phone usage while driving further compounds impairment in individuals administered antihistamines. 2005 - 2023 WebMD LLC. Antihistamines work by preventing the effects of a substance called histamine, which is produced by the body. Haddad PM, Anderson IM. idone (Risperdal), ziprasidone (Geodon), Lurasi-done (Latuda), iloperidone (Fanapt), paliperidone (Invega), and asenapine, (Saphris). documented with the antiarrhythmic agents. Effects of fexofenadine, diphenhydramine, and placebo on performance of the test of variables of attention (TOVA). 2003:17:423-430. Background As a new generation antihistamine, fexofenadine has been widely used in allergic diseases. You should not use Geodon if you have a heart rhythm disorder, a history of long QT syndrome, uncontrolled heart failure, if you have recently had a heart attack, or if you are allergic to ziprasidone.