PLoS One. 2007 Aug; 47(2):307-9. His career has been replete with accomplishments in research, clinical work and administration, and at UCSD he is still able to round on patients, 2000 Jan; 118(1):90-100. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. J Clin Invest. Am J Physiol Gastrointest Liver Physiol. 2005 May; 41(5):1046-55. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Mar M, Clria J, Jimnez W, Arroyo V. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. 1992 Feb 28; 183(1):184-92. 2007 Nov; 46(5):1443-52. 2013 Jul; 145(1):16-31. J Gastroenterol Hepatol. 2000 Jun 01; 95(11):3568-77. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. 2019 07; 70(1):127-141. 1997 Nov; 113(5):1589-98. J Biol Chem. Hepatology. J Hepatol. Hepatology. 1991; 10(3-4):452-5. Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor EW. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. Migration of fibrocytes in fibrogenic liver injury. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Biotechniques. Hepatology. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. 2005 Aug; 43(2):317-23. 1988 Apr 25; 263(12):5841-5. 2018 12; 15(12):785. See more options in the Advanced Search tab. PLoS One. 2010 Mar; 51(3):1027-36. Dig Dis Sci. Hepatology. 2011 Jan; 53(1):4-6. Neurobiol Aging. Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S. Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. Le TA, Chen J, Changchien C, Peterson MR. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. Gut. Aliment Pharmacol Ther. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. 1991 Mar; 5(3):275-81. HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4- cell lines. 1988 Sep-Oct; 8(5):1040-5. 2015 Feb; 21(2):159-65. WebBrenners new job suits his eclecticism. Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. 1998 Jan 01; 160(1):410-8. Nat Rev Gastroenterol Hepatol. J Biol Chem. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Signal transduction during liver regeneration. Hattori M, Tugores A, Westwick JK, Veloz L. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. 2003 Mar 07; 278(10):8083-90. 2021 03; 18(3):151-166. 1993 Dec; 92(6):2916-21. 2011 Jul; 179(1):189-98. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. 2015 Dec; 149(7):1784-93. 2013 02 15; 177(4):333-42. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. 2021; 12(1):293-320. Trans Am Clin Climatol Assoc. Liver Int. Hepatology. HBO Special recorded in Las Bataller R, Paik YH, Lindquist JN, Lemasters JJ. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. Gastroenterology. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. J Clin Invest. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. 2020 01; 245(2):96-108. J Burn Care Rehabil. Hepatology. Hepatology. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. Semin Liver Dis. Hepatology. 1995; 255:342-59. People in Profiles who have published with this person. Carcinogenesis. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. Nat Immunol. 2013 Sep; 183(3):820-30. 2002 Aug 15; 100(4):1470-7. Stem Cells Cloning. Cell Metab. Rippe RA, Umezawa A, Kimball JP, Breindl M. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. 2007 Nov; 13(11):1324-32. 2017 03; 15(3):463-464. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. Akt activation protects rat liver from ischemia/reperfusion injury. 2003 Oct; 125(4):1009. Is it the end of the line for the EMT? Liver Int. 2017 Jun 16; 7:314-323. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. Schnabl B, Choi YH, Olsen JC, Hagedorn CH. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. Moderate alcohol drinking: effects on the heart and liver. 2006 Oct; 21 Suppl 3:S84-7. Signal transduction during liver regeneration. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. NK and NKT cells in liver injury and fibrosis. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. Thomas E. Starzl: Transplantation pioneer. Hepatology. Therapeutic strategies for hepatic fibrosis. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. Mol Endocrinol. 2007 Mar; 14(3):568-75. 2013 Feb; 57(2):577-89. Nat Commun. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG. DNA Cell Biol. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S. Hepatic stellate cells as a target for the treatment of liver fibrosis. 2020 Nov 03; 32(5):901. Am J Physiol Cell Physiol. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. 2005 Jan; 54(1):134-41. J Clin Invest. 2001 Aug 17; 89(4):351-6. Evidence for a common progenitor of epithelial and mesenchymal components of the liver. 2014 Dec; 26(12):1802-11. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Biochem Biophys Res Commun. Hepatology. 2013 Apr; 20(4):649-58. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Gastroenterology. 2012 Aug 31; 337(6098):1094-7. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. Int J Biochem Cell Biol. Hepatology. 2017 12; 1(10):1043-1057. 2001 Jan; 33(1):81-90. 2003 Jan 10; 278(2):927-33. 1995; (33):212-4. Alcohol Clin Exp Res. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. Molecular pathogenesis of alcohol-induced hepatic fibrosis. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. J Biol Chem. J Exp Med. N Engl J Med. Moore-Morris T, Guimar?es-Camboa N, Banerjee I, Zambon AC. CCR1 and CCR5 promote hepatic fibrosis in mice. 2017 Feb 01; 312(2):C131-C143. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical 2005 Jun; 42(6):850-9. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. 2022 Apr 04. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Regulation of collagen alpha1(I) expression in hepatic stellate cells. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. 2016 05; 139(Pt 5):e28. Analysis of the collagen alpha 1(I) promoter. 2005; 23(3-4):255-63. 2020; 144(8):400-412. 2013 Aug; 20(8):1116-23. J Stroke Cerebrovasc Dis. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A. Porphyrias. To see the data as text. 1989 Aug 11; 17(15):6055-64. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. Am J Physiol Gastrointest Liver Physiol. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Hepatology. 2013 Nov; 9(11):737-9. 2014 Apr 29; 63(16):1626-33. 1998 Jul 01; 92(1):320-8. Cell Death Differ. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. 1993 Apr; 264(4 Pt 1):G589-95. 2022 07 05; 34(7):978-990.e4. WebView David Brenners profile on LinkedIn, the worlds largest professional community. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. 2018 12; 16(12):1974-1982.e7. 1999 Aug; 31(4):305-19. 2009 Mar 03; 106(9):3300-5. 2021 08 01; 321(2):H435-H445. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. Am J Physiol Gastrointest Liver Physiol. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ. 1990 Apr; 7(2):105-15. Gastroenterology. 2005 Sep-Oct; 7(9-10):1346-55. 2012; 5(Suppl 1):S17. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Am J Physiol. Nucleic Acids Symp Ser. 2020 Apr; 4(4):606-626. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. 2000; 35 Suppl 12:80-3. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. 1994 Jun 21; 91(13):6030-4. 1996 Dec 15; 98(12):2771-8. 2011 Apr; 25(2):305-17. Alcohol Clin Exp Res. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. New Approaches for Studying Alcoholic Liver Disease. 1998 Aug; 115(2):443-51. 2000; 32(1 Suppl):32-8. 2002 Sep; 123(3):877-8. 2006 Nov; 291(5):G877-84. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. 2022; 17(9):e0274219. Am J Physiol. Aliment Pharmacol Ther. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. What's new in liver fibrosis? J Hepatol. 2015 Apr 06; 212(4):469-80. 2005 Jul 29; 280(30):27879-87. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. Am J Physiol Heart Circ Physiol. 2007 Apr-Jun; 6(2):83-8. Hepatology. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. 2016 08; 65(2):369-76. 2003 Mar; 37(3):493-503. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Clin Gastroenterol Hepatol. 2010 Jul; 26(4):395-402. Alteration of interferon-a/ receptors in chronic hepatitis B patients. 2019 10; 68(10):1884-1892. I. TNF-induced liver injury. J Biol Chem. Neurology. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. 2007 Apr; 132(4):1434-46. Fibrogenesis Tissue Repair. 1994 Dec; 124(6):755-60. 2021; 8:790032. J Cell Biol. Clin Liver Dis. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! Hepatology. 2008 Feb; 25(2):249-58. Alcohol Clin Exp Res. 2016 Mar; 13(3):126-8. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. New therapies for hepatic fibrosis. Hepatology. 2015 Jan; 22(1):164-73. Hellerbrand C, Jobin C, Licato LL, Sartor RB. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. 2022 08; 42(3):233-249. WebDavid Brenner. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. 2007 Dec; 133(6):2019-28. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. 1998 Jun; 42(6):779-87. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA. J Gastroenterol Hepatol. Hepatology. J Hepatol. 2002 Nov; 70(11):6294-301. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ. 2006 May; 130(6):1564-72. Nat Commun. He will assume his new role effective September 14. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. J Gastroenterol Hepatol. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Mechanisms of fibrogenesis. New Developments on the Treatment of Liver Fibrosis. 2005 Dec; 42(6):1320-8. 2004 Apr; 18(6):720-2. Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. Am J Physiol Gastrointest Liver Physiol. Molecular and cellular biology of the small intestine. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. Clinical syndromes of alcoholic liver disease. Hepatology. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. 2004 Jun; 135(6):619-28. 1990 Jan; 85(1):248-55. Am J Physiol. 2017 01; 65(1):78-88. Hepatology. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH. Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. 2011 Jun; 31(3):521-32. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. 2008 Jul; 255(7):993-1000. Am J Physiol. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y. 2011 Aug; 35(8):1509-18. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. 2000 Apr 21; 275(16):12207-13. Hepatology. Hepatology. 1990 Nov; 26(11):1011-23. Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. Mol Cell Biol. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E. The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. Allergy. 2001 Jul 01; 167(1):173-80. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. 1998 Sep; 13 Suppl:S93-5. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. 2021 09; 191(9):1564-1579. Mol Cell Biol. 2022 10; 610(7931):366-372. 1995 Sep; 9(9):1157-65. 2000 Dec; 279(6):G1333-42. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu 1999 Apr 15; 162(8):4447-54. 2017 May 02; 25(5):1054-1062.e5. Am J Physiol. 1989 May; 8(4):279-85. 2002 Oct; 4(5):769-81. 2003 Apr; 27(4):726-31. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Hepatology. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. 1992 Sep 04; 70(5):777-89. 2022 07; 10(7):e1953. Biochem Soc Symp. Compr Ther. 1993 Jan; 264(1 Pt 1):G95-103. J Hepatol. Hum Mol Genet. 2001 May; 25(5 Suppl ISBRA):251S-253S. J Gastroenterol Hepatol. WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. 2003 Mar; 37(3):653-64. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. University of California San Diego named John M. Carethers as the vice chancellor for Health Sciences (VCHS), effective January 1, 2023. 2010 Oct; 52(4):1420-30. 1996 Nov; 271(5 Pt 1):G780-90. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Ital J Gastroenterol Hepatol. 2017 Jun 30; 127(7):2697-2704. 2005 Sep 16; 335(1):87-96. 1999; 8(3):151-63. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM. Exercise training attenuates age-associated diastolic dysfunction in rats. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. 2018 06; 67(6):2150-2166. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. J Biol Chem. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Molecular mechanisms of alcohol-induced hepatic fibrosis. 1993 Feb; 17(2):287-92. J Biol Chem. 1999 Oct 22; 274(43):30919-26. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. J Biol Chem. Cell Metab. 2013 Mar 01; 3(1):4-11. 1994 Sep; 3(9):1695-7. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. 2018 09; 68(3):1070-1086. Proc Natl Acad Sci U S A. Exp Biol Med (Maywood). 2015 Sep; 42(5):582-90. 2008 Feb; 47(2):677-85. Kenji Fujiwara, MD, PhD. Gastroenterology. 2006 Jul; 86(7):676-86. Awareness, treatment, and control of vascular risk factors among stroke survivors. 2008 Mar; 23 Suppl 1:S98-103. Infect Immun. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). Adv Second Messenger Phosphoprotein Res. J Surg Res. 2012 Nov; 122(11):4280-2. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Immunol. Luedde T, Rodriguez ME, Tacke F, Xiong Y. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. Gastroenterology. Transplantation. 1993 Sep; 92(3):1336-48. Transient induction of c-jun during hepatic regeneration. 2007 Dec; 52(12):3404-15. Gastroenterol Hepatol (N Y). 2009 Jan; 130(1):16-26. J Clin Immunol. 2010 Feb; 16(2):181-90. 2016 Feb 10; 19(2):227-39. 1992 Jul-Aug; 11(6):443-52. J Biol Chem. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. J Clin Invest. 2017 Aug; 40(2):454-464. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B. Mechanisms of alcoholic liver disease: cytokines. Leadership - Institute for Diabetes and Metabolic Health - UC San Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. 2007 Dec 07; 249(3):518-31. 2012 Nov; 67(11):1357-64. J Biol Chem. Clin Gastroenterol Hepatol. Hepatology. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Am J Pathol. 2000 Aug; 119(2):446-60. Am J Physiol. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. Hepatology. People who share similar concepts with this person. Am J Physiol Gastrointest Liver Physiol. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. 2001 Jan; 280(1):G139-48. 2009 Sep; 1(8-9):513-24. 1990 Feb; 10(1):75-83. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. The InTeam is led by Dr. Ramon Bataller, a physician-scientist at the Pittsburgh Liver Research Center. Cancer Detect Prev. Circ Res. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. Clin Gastroenterol Hepatol. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. Am J Gastroenterol. 2008 Jun; 118(6):2121-31. Gut. 2014 Dec; 60(6):1920-8. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA. Int J Mol Sci. Am J Physiol. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. 2013; 8(2):e56116. Antioxid Redox Signal. Biochim Biophys Acta. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. 2021 11; 25(11):2149-2159. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. Fibrogenesis of parenchymal organs. 2022 08 02; 34(8):1201-1213.e5. Liver Int. Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury. Am J Physiol Gastrointest Liver Physiol. Hepatitis C and alcohol: fundamental and translational research directions. Hepatology. 2001 Jul 10; 104(2):221-6. Hepatology. 1999 Aug; 14(8):1272-80. J Hepatol. Cloning of murine ferrochelatase. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Hepatology. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Yang L, Bataller R, Dulyx J, Coffman TM, Gins P, Rippe RA. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. 2000 Dec; 32(6):1255-64. 1994 Sep; 14(9):5950-60. 1988 Apr 15; 48(8):2288-91. Proc Natl Acad Sci U S A. What goes up must come down: the emerging role of microRNA in fibrosis. Gbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW. Dig Liver Dis. 2001 Dec; 35(6):749-55. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. Am J Hum Genet. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. FASEB J. We lose people all of Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. 2012 Dec; 56(6):2316-27. 2004 Oct; 127(4):1260-2. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Proc Natl Acad Sci U S A. 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